Journals Information
Nanoscience and Nanoengineering(CEASE PUBLICATION) Vol. 2(1), pp. 1 - 9
DOI: 10.13189/nn.2014.020101
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Nanomedicine to Counter Syndemic Tuberculosis and HIV Infection: Current Knowledge and State of Art
Dipankar Seth *, Amit Sarkar , Debalina Mitra
Veterinary Officer, Animal Resources Development Department, Government of West Bengal, India
ABSTRACT
This review examines, current knowledge, of the impact of the HIV-TB disease syndemic with an eye on its zoonotic impact and discusses the current knowledge and the potential of nanomedicine to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen鈥檚 intracellular location. Besides the aim of this review is also to identify the gap between available medications and the need of the hour, drugs, to counter multi-drug resistance (mdr) and extensively drug-resistant (XDR) tuberculosis. This review is the first of its kind to take into consideration the multifaceted angles ranging from recent drugs to novel nano molecules, from human to avian tuberculosis and from ideal characteristics of TB drug to where we stand now. Vaccine against tuberculosis is beyond the scope of this review. Key messages: There exists a major gap between the present state of art of drugs available to combat tuberculosis and the present multifaceted complications of the disease like Drug resistance, adverse drug reactions, etc. Drugs for tuberculosis failed to address the basic inherent problems like intracellular drug delivery etc. Thus requires new technology intervention. Transmissions from non human sources have been often overlooked. Complete eradication of TB is not possible in a piecemeal approach. Nanoparticles find various applications in biomedical and material science research due to the tuning-ability of their physicochemical properties such as shape, size, charge, surface group, etc. Nanoparticles might provide a cutting edge to counter MDR/XDR TB and its co infection with HIV by novel mechanism of action.
KEYWORDS
Tuberculosis, HIV, Nanomedicine, Nanosilver
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Dipankar Seth , Amit Sarkar , Debalina Mitra , "Nanomedicine to Counter Syndemic Tuberculosis and HIV Infection: Current Knowledge and State of Art," Nanoscience and Nanoengineering(CEASE PUBLICATION), Vol. 2, No. 1, pp. 1 - 9, 2014. DOI: 10.13189/nn.2014.020101.
(b). APA Format:
Dipankar Seth , Amit Sarkar , Debalina Mitra (2014). Nanomedicine to Counter Syndemic Tuberculosis and HIV Infection: Current Knowledge and State of Art. Nanoscience and Nanoengineering(CEASE PUBLICATION), 2(1), 1 - 9. DOI: 10.13189/nn.2014.020101.