Journals Information
Advances in Pharmacology and Pharmacy Vol. 2(2), pp. 13 - 17
DOI: 10.13189/app.2014.020201
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Formulation Development and Evaluation of Venlafaxine HCL Buccal Patch
Anand G. Mundhe 1,*, Gokul A. Khairnar 2, Sadik F. Sayyad 3
1 Dept. of Pharmaceutics S.M.B.T College of Pharmacy, Nandi Hills, Dhamangaon, Tal. Igatpuri, Dist. Nasik (M.S) -422 403
2 Department of Pharmaceutical Technology, University Institute of Chemical Technology, North Maharashtra University, Jalgaon, 425 001, Maharashtra
3 Dept. of pharmaceutics Amrutvahini College of pharmacy Sagamner, Ahmadnagar, Maharashtra
ABSTRACT
Within the oral mucosal cavity, the buccal region offers an attractive route of administration for Systemic patches. Venlafaxine were Prepared using HPMC K4M, Pectin, and poly vinyl Pyrrolidone, PG as Plasticizers. FTIR and UV spectroscopic and DSC methods revealed that there is no interaction between Venlafaxine and polymers. The patches were evaluated for their thickness uniformity, folding endurance, Weight Uniformity, content uniformity, Swelling behaviour, tensile strength, Mucoadhesion strength and Surface pH. In vitro release studies of Venlafaxine loaded patches in Phosphate buffer (pH, 6.8) exhibited 98 % drug release in the 8 h. The optimized patch was obtained good in vitro result.
KEYWORDS
Bioadhesion, Buccal Patch, Pectin, Venlafaxine HCL, HPMC K4M, Drug Release
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Anand G. Mundhe , Gokul A. Khairnar , Sadik F. Sayyad , "Formulation Development and Evaluation of Venlafaxine HCL Buccal Patch," Advances in Pharmacology and Pharmacy, Vol. 2, No. 2, pp. 13 - 17, 2014. DOI: 10.13189/app.2014.020201.
(b). APA Format:
Anand G. Mundhe , Gokul A. Khairnar , Sadik F. Sayyad (2014). Formulation Development and Evaluation of Venlafaxine HCL Buccal Patch. Advances in Pharmacology and Pharmacy, 2(2), 13 - 17. DOI: 10.13189/app.2014.020201.