Journals Information
Advances in Pharmacology and Pharmacy Vol. 10(1), pp. 1 - 7
DOI: 10.13189/app.2022.100101
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In vivo Anticoagulant Activity of Immediate Release Tablets of Dabigatran Etexilate Mesylate Cocrystals
Ashwini Gawade 1,*, Sanjay Boldhane 2, Anil Pawar 1, Rohini Pujari 1, Ashwin Kuchekar 1
1 School of Pharmacy, Dr. Vishwanath Karad Maharashtra Institute of Pharmacy (MIP), World Peace University, Kothrud, Pune - 411038, Maharashtra, India
2 Development Micro Labs Limited, Micro Advanced Research Centre (Marc.), No. 58/3, Kudlu Village, Anekal Taluk, Singasandra Post Bangalore - 560068, Karnataka, India
ABSTRACT
Dabigatran Etexilate Mesylate (DEM), a salt of prodrug dabigatran etexilate, is a potent, oral, reversible and direct thrombin inhibitor with low oral bioavailability. The present research investigation focused on the formulation of immediate release (IR) tablets of DEM cocrystals and evaluation of In vivo anticoagulant activity. The results of the study showed that the formulated IR tablets of DEM showed improved efficacy in comparison with the plain drug by enhancing the pre-compression parameters such as bulk density, tap density, Carr's index, angle of repose and Hausner's ratio and post-compression parameters like thickness and weight variation, hardness and friability, In vitro dissolution parameters. The improved efficacy was confirmed by improvement in the pharmacodynamic parameters such as cutaneous bleeding time and clotting time indicative of enhanced bioavailability of dabigatran. Thus, it can be concluded that the IR tablets of dabigatran cocrystals can be proven to be more effective in producing the anticoagulant effect in clinical practice as compared to the plain drug resulting in more patient compliance.
KEYWORDS
Dabigatran Etexilate Mesylate, Cocrystals, Anticoagulant, Immediate Release, Cutaneous Bleeding, Clotting Time
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Ashwini Gawade , Sanjay Boldhane , Anil Pawar , Rohini Pujari , Ashwin Kuchekar , "In vivo Anticoagulant Activity of Immediate Release Tablets of Dabigatran Etexilate Mesylate Cocrystals," Advances in Pharmacology and Pharmacy, Vol. 10, No. 1, pp. 1 - 7, 2022. DOI: 10.13189/app.2022.100101.
(b). APA Format:
Ashwini Gawade , Sanjay Boldhane , Anil Pawar , Rohini Pujari , Ashwin Kuchekar (2022). In vivo Anticoagulant Activity of Immediate Release Tablets of Dabigatran Etexilate Mesylate Cocrystals. Advances in Pharmacology and Pharmacy, 10(1), 1 - 7. DOI: 10.13189/app.2022.100101.