Journals Information
Advances in Pharmacology and Pharmacy Vol. 11(1), pp. 46 - 56
DOI: 10.13189/app.2023.110105
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Synthesis and Anti Convulsant Activity of "N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives"
Rohit Jaysing Bhor 1,*, Komal Sakharam Sable 1, Mayur Shivaji Bhosale 1, Santosh Bhausaheb Dighe 2
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Tal-Rahata, District-Ahmednagar, Maharashtra, India
2 Department of Pharmacology, Pravara Rural College of Pharmacy Pravaranagar, Tal-Rahata, District-Ahmednagar, Maharashtra, India
ABSTRACT
Introduction: Benzimidazole is a heterocyclic hydrocarbon having unique basic structural characteristics in their structure. This moiety was formed by using aromatic benzene and imidazole heterocylic ring. This molecule gives great application in biological and clinical studies. Benzimidazole and its derivatives have versatile Nitrogen containing heterocyclic compounds that give a promising category of biologically active compounds and possess a wide selection of biological activities like antibacterial drug, medicament, anti-ulcer, anti-diabetic, etc. Objective: Several scientists have declared that benzimidazole system possesses the variable sites like the position of a pair and five which might be fittingly changed to yield potent therapeutic agents. The current review covers the chemistry and medicine activities of substituted benzimidazoles. Materials & Methods: Formic acid; Acetyl Chloride; Hydrazine; Benzene-1,2-diol; Glycolic Acid; Benzoyl Chloride; Methyl Chloride; Ethyl Chloride; Benzamide etc. and methods are TLC, IR spectra, 1H-NMR and MS. Results & Conclusion: The pharmacological screening was done by using PTZ Induced Convulsion Method for anticonvulsant activity. The synthesize compounds were established to be BA to BK. The compound BA, BC, BJ, BI and BK were established to be the most potent compound through the comparison with standard drugs phenytoin. Synthesized newer benzimidazole derivatives were screened for Anti-convulsant activity. It was seen that in biological activity, derivatives containing 2-nitro aniline and 3-nitro aniline have more significant biological activities than other benzimidazole derivatives. Total 11 compounds (4 Step Products + 7 Benzimidazole Derivatives) were evaluated for their biological screening.
KEYWORDS
Benzimidazole, Hydroxy Acetic Acid, Benzene-1, 2-diol, 2-Nitro Aniline, PTZ, Anti Convulsant Activity
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Rohit Jaysing Bhor , Komal Sakharam Sable , Mayur Shivaji Bhosale , Santosh Bhausaheb Dighe , "Synthesis and Anti Convulsant Activity of "N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives"," Advances in Pharmacology and Pharmacy, Vol. 11, No. 1, pp. 46 - 56, 2023. DOI: 10.13189/app.2023.110105.
(b). APA Format:
Rohit Jaysing Bhor , Komal Sakharam Sable , Mayur Shivaji Bhosale , Santosh Bhausaheb Dighe (2023). Synthesis and Anti Convulsant Activity of "N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives". Advances in Pharmacology and Pharmacy, 11(1), 46 - 56. DOI: 10.13189/app.2023.110105.