Journals Information
Advances in Zoology and Botany Vol. 11(1), pp. 67 - 73
DOI: 10.13189/azb.2023.110107
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In-vitro Antiplasmodial Efficacy of a Poly Herbal Formulation against Plasmodium falciparum (3D7 Strain)
Jyotirmoy Thakuria 1,*, Manalisha Deka 2
1 Department of Molecular Biology and Biotechnology, Tezpur University, 784028, Assam, India
2 Department of Zoology, BBK College, Barpeta-781311, Assam, India
ABSTRACT
Malaria is one of the world's leading killer infectious diseases accounting for about 241 million cases of infection and 627000 deaths all around the globe in the year of 2021. In the present study, a polyherbal formulation used by traditional drug practitioners to cure malarial infection in some rural areas of Barpeta district of Assam, India was tested in vitro for its antiplasmodial and antioxidant properties. Two plant species namely Aristolochia indica L. and Piper nigrum L. were used for the herbal formulation. Water extract along with other organic solvent extracts viz. Chloroform, 2-propanol, methanol and n-hexane was tested in the experiment. Methanol and 2-propanol extracts in high concentration (50碌g/ml) showed promising antiplasmodial effect in 3D7 strain of Plasmodium falciparum. Water extract showed promising antioxidant properties along with methanolic extract. This preliminary study conclusively established the antiplasmodial and antioxidant properties of the traditionally used polyherbal formulation. Further studies are required for the exploration of bioactive compounds from this formulation. Scientific validation of such traditional practices is important not only because there is an urgent need for alternative medication against diseases like malaria, but it is also important from the conservation point of view. These traditional herbal remedies lack proper documentation in scientific literature and the need of the hour is to explore their potential and proper documentation.
KEYWORDS
Alternative Medication, Aristolochia indica L., Malaria, Piper nigrum L., Polyherbal Formulation, Organic Solvent Extracts
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Jyotirmoy Thakuria , Manalisha Deka , "In-vitro Antiplasmodial Efficacy of a Poly Herbal Formulation against Plasmodium falciparum (3D7 Strain)," Advances in Zoology and Botany, Vol. 11, No. 1, pp. 67 - 73, 2023. DOI: 10.13189/azb.2023.110107.
(b). APA Format:
Jyotirmoy Thakuria , Manalisha Deka (2023). In-vitro Antiplasmodial Efficacy of a Poly Herbal Formulation against Plasmodium falciparum (3D7 Strain). Advances in Zoology and Botany, 11(1), 67 - 73. DOI: 10.13189/azb.2023.110107.