Journals Information
Advances in Pharmacology and Pharmacy Vol. 11(3), pp. 179 - 186
DOI: 10.13189/app.2023.110301
Reprint (PDF) (844Kb)
Antioxidant, Anti-Microbial, Anti-Inflammatory and Cytotoxic Effect of Macrotyloma Uniflorum Leaf Extract
Arun Kumar Kashyap 1,*, Padmini Bisoyi 2, Buddhi Prakash Jain 3
1 Department of Biotechnology, Govt. E Raghavendra Rao PG. Science College, India
2 School of Life Sciences, Jawaharlal Nehru University, India
3 Department of Zoology, Mahatma Gandhi Central University, India
ABSTRACT
Macrotyloma uniflorum (Horse gram), a legume plant with medicinal properties is used as a tonic, diuretic and in the treatment of rheumatism and neurological disorders. The present study was undertaken to find the anti-microbial, anti-inflammatory, the antioxidant, and cytotoxic activity of leaf extract of Macrotyloma uniflorum. Extract of the Macrotyloma uniflorum leaf was prepared in the hexane, ethyl acetate, methanol solvent and analyzed for phytochemicals composition. Total flavonoid and phenolic contents, antioxidants, and free radical scavenging capacity were determined and found to be high in methanolic and ethyl acetate extract compared to the Hexane extract. The methanolic extract showed higher anti-microbial activity and anti-inflammatory activity. Methanolic extract of Macrotyloma uniflorum leaf has the anti-microbial, antioxidant, and anti-inflammatory properties. The leaf extract of the Macrotyloma uniflorum also shows cytotoxic effects in breast cancer cell line (MCF-7) in a dose dependent manner which was further confirmed by FACS analysis. This study highlights the potential of the methanolic extract of leaves of Macrotyloma uniflorum -as an antioxidant, anti-inflammatory, cytotoxic and anti-microbial agent.
KEYWORDS
Medicinal Plant, Antioxidant, Anti-Microbial, Anti-Inflammatory, Cytotoxic, Macrotyloma
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Arun Kumar Kashyap , Padmini Bisoyi , Buddhi Prakash Jain , "Antioxidant, Anti-Microbial, Anti-Inflammatory and Cytotoxic Effect of Macrotyloma Uniflorum Leaf Extract," Advances in Pharmacology and Pharmacy, Vol. 11, No. 3, pp. 179 - 186, 2023. DOI: 10.13189/app.2023.110301.
(b). APA Format:
Arun Kumar Kashyap , Padmini Bisoyi , Buddhi Prakash Jain (2023). Antioxidant, Anti-Microbial, Anti-Inflammatory and Cytotoxic Effect of Macrotyloma Uniflorum Leaf Extract. Advances in Pharmacology and Pharmacy, 11(3), 179 - 186. DOI: 10.13189/app.2023.110301.