Journals Information
International Journal of Biochemistry and Biophysics(CEASE PUBLICATION) Vol. 11(1), pp. 1 - 8
DOI: 10.13189/ijbb.2023.110101
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A Spectrum of Hemoglobinopathies and Thalassemia Trait Using HPLC: Hospital-Based Observational Study in Northern India
Saroj Prasad Shah *, Akhil Bansal , Siddhant Gautam , Kaushal Kumar Gupta , Rina Das , Dinesh Kumar Mehta
College of Pharmacy, Maharishi Markandeshwar University, India
ABSTRACT
Aim: The publication deals with the prevalence of hemoglobinopathies among patients diagnosed with thalassemia based on High Performance Liquid Chromatography (HPLC) characteristics. We also compared the current study results to other published studies. Hemoglobinopathies, which can be quantitative (such as thalassemia syndrome) or qualitative (such as sickle cell disease), are a major public health concern in India (variant hemoglobinopathies). Every year, 10,000 infants are born in India with thalassemia major, accounting for 10% of all such children globally. According to the Thalassemia International Federation, around 0.2 million thalassemia major cases are alive and undergoing regular treatment globally. HPLC is regarded as a sensitive and specific method for detecting hemoglobin A2 (HbA2) levels greater than 3.5%, which is used to diagnose beta thalassemia trait (BTT). This study was conducted at a tertiary care hospital, where laboratory test reports of patients, who were diagnosed with thalassemia utilizing HPLC test from January 2022 to December 2022 were studied and analyzed. The age categories of 21 to 30 years were discovered to have the highest prevalence of beta-thalassemia features (36.9%), followed by 31 to 40 years (13.8%) and 11 to 20 years (11.3%). The data was displayed in the following formats: mean (average), median, standard deviation (SD), lowest and maximum range. HbF varied from more than 0.08 to 40.0, HbA2 from 1.5 to 27, and HbA0 from 52.5 to 95.5. The results of this investigation demonstrated the prevalence and range of hemoglobinopathies and thalassemia in patients. The coexistence of thalassemia and other hemoglobin variants was discovered to be frequent.
KEYWORDS
Hemoglobinopathies, 螔-Thalassemia, High Performance Liquid Chromatography, Anemia, Hemoglobin A2
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Saroj Prasad Shah , Akhil Bansal , Siddhant Gautam , Kaushal Kumar Gupta , Rina Das , Dinesh Kumar Mehta , "A Spectrum of Hemoglobinopathies and Thalassemia Trait Using HPLC: Hospital-Based Observational Study in Northern India," International Journal of Biochemistry and Biophysics(CEASE PUBLICATION), Vol. 11, No. 1, pp. 1 - 8, 2023. DOI: 10.13189/ijbb.2023.110101.
(b). APA Format:
Saroj Prasad Shah , Akhil Bansal , Siddhant Gautam , Kaushal Kumar Gupta , Rina Das , Dinesh Kumar Mehta (2023). A Spectrum of Hemoglobinopathies and Thalassemia Trait Using HPLC: Hospital-Based Observational Study in Northern India. International Journal of Biochemistry and Biophysics(CEASE PUBLICATION), 11(1), 1 - 8. DOI: 10.13189/ijbb.2023.110101.