Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 28 - 36
DOI: 10.13189/app.2025.130104
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Anticataract Activity of Abrus precatorius Seed Extract against Diabetic-induced Cataract
Princy Kashyap 1, Apurva Yadav 1,2, Rajesh Choudhary 1,*, Hemlata Sahu 1, Jaya Shree 2, Arvind Kumar Jha 3
1 Kamala Institute of Pharmaceutical Sciences, Shri Shankaracharya Professional University, Bhilai-490020, Chhattisgarh, India
2 Shri Shankaracharya College of Pharmaceutical Sciences, Shri Shankaracharya Professional University, Bhilai-490020, Chhattisgarh, India
3 Faculty of Pharmaceutical Sciences, Shri Shankaracharya Professional University, Bhilai-490020, Chhattisgarh, India
ABSTRACT
Cataract is the leading cause of ocular blindness, which mostly occurs in diabetic conditions. In this work, we evaluated the anticataract activity of ethanolic extract of seeds of Abrus precatorius (APEE) against the glucose-induced model in goat lenses (ex-vivo) and the STZ-induced model in albino rats (in-vivo). In the ex-vivo model, goat lenses were incubated in Tyrode solution containing 55 mM glucose for induction of cataract, and APEE (100 and 200 渭g/ml) was assessed against high concentrations of glucose. In the in-vivo STZ-induced model, albino Wistar rats (both sexes, 150-180 g) were treated with a single intraperitoneal injection of streptozotocin (60 mg/kg) for induction of diabetic cataract. After induction of diabetes, STZ-treated rats received APEE (0, 100, or 200 mg/kg/day, p.o.) for the next twelve weeks for assessment of the anticataract activity. Blood glucose level, lens transparency, lens protein contents, and oxidative stress markers were examined for the establishment of anticataract activity. APEE treatments showed potent anticataract activity against both ex-vivo and in-vivo models. When compared to the STZ control group, APEE treatments significantly (P < 0.05) reduced the blood glucose levels, lipid peroxidation (MDA), nitrite content, and insoluble protein contents in lenses and significantly (P < 0.05) increased the antioxidants (CAT, SOD, GPx, and GSH) and soluble protein contents in lenses. We concluded that the ethanolic extract of Abrus precatorius seeds exhibited significant anti-cataract activity against ex-vivo and in-vivo animal models which could be due to its potent antioxidant activity.
KEYWORDS
Abrus precatorius, Antioxidants, Anticataract Activity, Diabetic Cataract, STZ-induced Model
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Princy Kashyap , Apurva Yadav , Rajesh Choudhary , Hemlata Sahu , Jaya Shree , Arvind Kumar Jha , "Anticataract Activity of Abrus precatorius Seed Extract against Diabetic-induced Cataract," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 28 - 36, 2025. DOI: 10.13189/app.2025.130104.
(b). APA Format:
Princy Kashyap , Apurva Yadav , Rajesh Choudhary , Hemlata Sahu , Jaya Shree , Arvind Kumar Jha (2025). Anticataract Activity of Abrus precatorius Seed Extract against Diabetic-induced Cataract. Advances in Pharmacology and Pharmacy, 13(1), 28 - 36. DOI: 10.13189/app.2025.130104.