Journals Information
Universal Journal of Public Health Vol. 12(6), pp. 1042 - 1050
DOI: 10.13189/ujph.2024.120602
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Serum High Mobility Group Box1 Protein and Toll-like Receptor 4 Correlation with Lipid Profile in Patients with Non-alcoholic Fatty Liver Disease
Bharateesh Yadav H 1, Poornima Ajay Manjrekar 1, Anupama Hegde 1, Santhosh Rai 2, Sindhu 1,*
1 Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India.
2 Department of Radiodiagnosis, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India
ABSTRACT
Background: HMGB1 (high mobility group box1 protein) extracellularly acts as a cytokine in response to free fatty acids (FFA) infusion to the liver in which TLR4 (toll-like receptor4) is a receptor for HMGB1 to generate the inflammatory response and it is responsible for the emergence of Non-alcoholic fatty liver disease (NAFLD). This study aimed to correlate the HMGB1 and TLR4 with lipid profile in NAFLD patients with dyslipidemia. Methods: This prospective study included NAFLD patients with dyslipidemia (n=87) with a mean age of 50.5卤6.25, of which 54 were males and 33 were females. Data for the lipid profile and liver enzyme parameters except HMGB1 and TLR4 were collected from the data management system of the central laboratory. HMGB1 and TLR4 values were estimated by enzyme-linked immunosorbent assay (ELISA) method, statistically Karl Pearson's, spearmen's correlation and Independent t-test, Mann-Whitney U-test were applied to find the correlation and comparison of HMGB1 and TLR4 with lipid profile and liver enzymes based on the age group and gender respectively. Results: No correlation was observed with the HMGB1 and TLR4 with lipid profile in NAFLD patients. Additionally, it was noted that the comparison study of AST/ALT ratio with gender showed a significant difference but not with HMGB1 and TLR4. Conclusion: Males were affected earlier than females. The study group had significantly higher levels of LDL-cholesterol as against the treatment goals. Levels of extracellular HMGB1, which is a damage-associated molecular pattern (DAMP) were found to be elevated, similar to the findings with TLR4 levels which act as a receptor for HMGB1. However, we did not find a correlation of HMGB1 and TLR4 with lipid profile in non-alcoholic fatty liver disease.
KEYWORDS
Aspartate Transaminase/Alanine Transaminase Ratio, High Mobility Group Box1 Protein, Non-alcoholic Fatty Liver Disease, Toll-like Receptor 4, Triglycerides, Low-density Lipoprotein-cholesterol
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Bharateesh Yadav H , Poornima Ajay Manjrekar , Anupama Hegde , Santhosh Rai , Sindhu , "Serum High Mobility Group Box1 Protein and Toll-like Receptor 4 Correlation with Lipid Profile in Patients with Non-alcoholic Fatty Liver Disease," Universal Journal of Public Health, Vol. 12, No. 6, pp. 1042 - 1050, 2024. DOI: 10.13189/ujph.2024.120602.
(b). APA Format:
Bharateesh Yadav H , Poornima Ajay Manjrekar , Anupama Hegde , Santhosh Rai , Sindhu (2024). Serum High Mobility Group Box1 Protein and Toll-like Receptor 4 Correlation with Lipid Profile in Patients with Non-alcoholic Fatty Liver Disease. Universal Journal of Public Health, 12(6), 1042 - 1050. DOI: 10.13189/ujph.2024.120602.