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Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 627 - 638
DOI: 10.13189/app.2025.130413
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Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles
Raghavendra Kumar Gunda 1,*, A. Vijayalakshmi 2, Prathap Madeswara Guptha 3, Koteswara Rao GSN 4, Kondapuram Parameshwar 5, Madhavi Latha Chennuru 6
1 Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences (Autonomous), Narasaraopet, Andhra Pradesh, India
2 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India
3 Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Guntur, India
4 Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai, Maharashtra, India
5 Department of Pharmaceutics, Guru Nanak Institutions Technical Campus- School of Pharmacy, Hyderabad, Telangana, India
6 Department of Pharmacology, Sree Venkateswara College of Pharmacy, Nellore, Andhra Pradesh, India
ABSTRACT
Objective: The purpose of the present research work was to develop Sulforaphane loaded magnetic nanoparticles (MNPs) and the effect of prepared magnetic nanoparticle on the enhancement of bioavailability, stability, and dissolution was studied. Sulforaphane (SFP) is a naturally occurring isothiocyanate and chiefly available in broccoli. Methods: Magnetic Nanoparticles were prepared by encapsulating herbal drug SFP with iron salts and the prepared magnetic nanoparticles were analyzed by Infrared Spectroscopy, Crystal Analysis, Scanning Electron Microscope (SEM), Thermal Analysis, Drug Loading Efficiency, Magnetic Analysis, Electrical Analysis and Stability Studies. Results: The obtained data of the characterization studies reveal that the magnetic nanoparticles (MNPs) have good holding properties. The particles sizes of MNPs measured from High Resolution Scanning Electron Microscopy (HRSEM) were of ideal size range 100 - 250 nm and showed a regular pattern of spherical shape. The Vibrating Sample Magnetism (VSM) results showed satisfactory value. The pH of the medium has an inverse relationship with the amount of Sulphoraphane released by the MNPs. Conclusion: From the results, the current study concludes that the prepared MNPs (four types) are structurally arranged following a good pattern, sufficient amount of elements with good size range over the particle surface, and exhibit magnetic responsiveness which is sufficient for drug target due to an external magnetic field because of its pore volume and large surface area. Dissolution study reveals that the prepared Sulforaphane loaded MNPs of Iron-MCM-41 showed maximum drug release at pH 5.5.
KEYWORDS
Sulforaphane, Magnetic Nanoparticles, FT-IR, Co-Precipitation Method
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Raghavendra Kumar Gunda , A. Vijayalakshmi , Prathap Madeswara Guptha , Koteswara Rao GSN , Kondapuram Parameshwar , Madhavi Latha Chennuru , "Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 627 - 638, 2025. DOI: 10.13189/app.2025.130413.
(b). APA Format:
Raghavendra Kumar Gunda , A. Vijayalakshmi , Prathap Madeswara Guptha , Koteswara Rao GSN , Kondapuram Parameshwar , Madhavi Latha Chennuru (2025). Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles. Advances in Pharmacology and Pharmacy, 13(4), 627 - 638. DOI: 10.13189/app.2025.130413.