Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 652 - 661
DOI: 10.13189/app.2025.130415
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Madhuca indica Leaf Extract: A Promising Candidate for the Treatment of Neuroprotective Effects
Vidhan Chand Bala 1,*, Bhawna Diwakar 1, Arvind Kumar Patel 2, Sushil Kumar 1
1 School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244102, India
2 Narayan Institute of Pharmacy, Gopal Narayan Singh University, Rohtas, Bihar, 821305, India
ABSTRACT
The recent trend worldwide is searching for plant extracts to prevent neurodegenerative disorders. The aim of this study is to conduct the phytochemical screening to explore neuroprotective effects of Madhuca indica leaf ethanol extract (MLE) in rats. Chemical composition was screened by using phytochemical screening tests and HPTLC methods. The neuroprotective effect was analyzed by Immobilized stress tolerance test, Elevated plus maze test, and Morris water maze test. The result of this study reflected that ethanolic extract from Madhuca Indica leaves was valuable in all methods in the dose-dependence approach. The findings show that, in comparison to the amnesia control group, the MLE significantly lowered the levels of metabolic markers like glucose, cholesterol, urea, and nitrogen increased escape latency (EL), and lowered the transfer latency (TL). Based on the aforementioned useful animal study, we have determined that MLE considerably affects neuroprotective activity compared to the amnesia control group. We may therefore conclude that Madhuca indica is highly successful in all test models and that it may be utilized to treat CNS illnesses by enhancing their effects and minimizing their negative effects in combination with currently marketed medications.
KEYWORDS
Neuroprotective Effect, Alzheimer's Disease, Madhuca indica, HPTLC, Escape Latency, Transfer Latency, Oxidative Stress
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Vidhan Chand Bala , Bhawna Diwakar , Arvind Kumar Patel , Sushil Kumar , "Madhuca indica Leaf Extract: A Promising Candidate for the Treatment of Neuroprotective Effects," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 652 - 661, 2025. DOI: 10.13189/app.2025.130415.
(b). APA Format:
Vidhan Chand Bala , Bhawna Diwakar , Arvind Kumar Patel , Sushil Kumar (2025). Madhuca indica Leaf Extract: A Promising Candidate for the Treatment of Neuroprotective Effects. Advances in Pharmacology and Pharmacy, 13(4), 652 - 661. DOI: 10.13189/app.2025.130415.