Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 674 - 685
DOI: 10.13189/app.2025.130417
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Exploring Extrusion-Spheronization for Pediatric Pellet Formulations: A Comprehensive Overview
Hitarthi Patel , Meenakshi Patel *, Lalit Lata Jha
School of Pharmacy, Faculty of Pharmacy, Parul University, India
ABSTRACT
When it comes to pharmacotherapy, children and adults have different abilities towards drug administration and taste acceptability. Pediatric medications must be designed to best meet the age of a child, physiologic condition, size, and therapeutic needs. The existing dosage forms available have various drawbacks, which result in poor pediatric patient compliance. This review explores the significance of pellet-based formulations in pediatric drug delivery, emphasizing the extrusion-spheronization technique as a versatile and effective method for developing multiparticulate oral dosage forms. Pellets produced through this method exhibit uniformity in size and shape, improved drug stability, controlled release profiles, and the potential for taste masking鈥攆eatures critical for ensuring accurate dosing and enhanced patient compliance in children. Furthermore, it provides an in-depth discussion of the fundamental principles of pellet development, detailing key stages such as nucleation, coalescence, layering, and abrasion. It also covers various pelletization techniques, with a special focus on extrusion-spheronization, highlighting its advantages over other methods. Factors influencing pellet quality, including formulation components (e.g., excipients, moisture content, granulating fluids) and process parameters (e.g., equipment type, extrusion speed, spheronization conditions), are thoroughly examined. Recent research studies and marketed products using extrusion-spheronization for pediatric applications are reviewed to exhibit the practical potential and clinical significance of this technology. These include taste-masked, fast-disintegrating, and dual-release pellet formulations designed to satisfy the specific needs of pediatric patients. The review concludes that extrusion-spheronization is a promising platform for developing innovative pediatric dosage forms that improve therapeutic outcomes and patient experience. By addressing existing limitations in pediatric drug delivery, this approach contributes to safer, more effective, and more acceptable treatments for children.
KEYWORDS
Extrusion-Spheronization, Pediatrics, Pellets, Patient Compliance
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Hitarthi Patel , Meenakshi Patel , Lalit Lata Jha , "Exploring Extrusion-Spheronization for Pediatric Pellet Formulations: A Comprehensive Overview," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 674 - 685, 2025. DOI: 10.13189/app.2025.130417.
(b). APA Format:
Hitarthi Patel , Meenakshi Patel , Lalit Lata Jha (2025). Exploring Extrusion-Spheronization for Pediatric Pellet Formulations: A Comprehensive Overview. Advances in Pharmacology and Pharmacy, 13(4), 674 - 685. DOI: 10.13189/app.2025.130417.