Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 686 - 692
DOI: 10.13189/app.2025.130418
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Investigation of Polyherbal Formulation as an Antihyperglycemic in Alloxan Induced Diabetic Rats
Shirode Devendra 1,*, Patil Aishwarya 1, Gauri Gawande 1, Agrawal Amit 2, Bindurani LGP Ram 3
1 Dr. D.Y. Patil College of Pharmacy, Sector 29, Pradhikaran, Akurdi Pune 411044, Maharashtra, India
2 Mauli College of Pharmacy, Latur, Maharashtra, India
3 SGMSPM's Dnyanvilas College of Pharmacy, Pune, India
ABSTRACT
Type 1 Diabetes is non-communicable chronic metabolic disease and the causes are due to autoimmunity destruction of beta cells of pancreas occurs along with dyslipidaemia. Type 1 diabetes become the main cause of mortality. Insulin is the only therapy still available for treatment of type 1 diabetes but has side effects. There is need to develop such a formulation which has base of herbal medicines. The current work's goal is to develop a polyherbal formulation (Hugonia Mystax: Blumea Lacera: 1:1) and investigate it against hyperglycaemia. Single dose of freshly prepared alloxan monohydrate (120mg/kg) was given to animals to introduce diabetes in rats. After 48 hours the animals were selected for treatment of polyherbal formulation for next 14 days. At the end of the study, evaluation of body weight, blood glucose level, lipid profile, glycosylated haemoglobin level and histopathological pancreas of rat were done. The result elaborated that polyherbal formulation showed significant reduction or normalization of parameters which were altered by induced alloxan. The results estimated support that polyherbal formulation has potential livelihood towards various anti-diabetic mechanisms specially on healing of damaged beta cells. The result of present study revealed polyherbal formulation has anti hyper glycaemic effect and anti-hyperlipidaemic activity by regulating blood glucose levels and lipid profile.
KEYWORDS
Hugonia Mystax, Blumea Lacera, Anti-Hyper Glycaemic, Glycosylated Haemoglobin, Alloxan
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Shirode Devendra , Patil Aishwarya , Gauri Gawande , Agrawal Amit , Bindurani LGP Ram , "Investigation of Polyherbal Formulation as an Antihyperglycemic in Alloxan Induced Diabetic Rats," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 686 - 692, 2025. DOI: 10.13189/app.2025.130418.
(b). APA Format:
Shirode Devendra , Patil Aishwarya , Gauri Gawande , Agrawal Amit , Bindurani LGP Ram (2025). Investigation of Polyherbal Formulation as an Antihyperglycemic in Alloxan Induced Diabetic Rats. Advances in Pharmacology and Pharmacy, 13(4), 686 - 692. DOI: 10.13189/app.2025.130418.