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Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 693 - 701
DOI: 10.13189/app.2025.130419
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Solid Lipid Nanoparticles: A Promising Approach for Depression

Shreya Jadyal ^*, Pallavi M. Chaudhari
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune – 411044, Maharashtra, India

ABSTRACT

Depression is one of the serious and common mental health problems. In a depressed state, one feels low, feeble, helpless, which ultimately affects the physical health, thoughts and normal functioning of life like (eating, sleeping). Oral administration is one of the non-invasive methods widely used to introduce antidepressants, which has high patient compliance as compared to invasive methods such as intracerebral, intrathecal, intracerebroventricular. But antidepressants include neuropeptides, natural active ingredients, and certain chemical agents whose bioavailability is restricted due to BBB and first-pass metabolism. To prevail over these challenges and enhance drug availability in the brain, researchers are exploring alternative delivery methods and novel formulations. The intranasal route is one such alternative that bypasses the BBB. Additionally, innovative formulations like solid lipid nanoparticles, gold nanoparticles, polymeric nanoparticles, dendrimers, nano emulsion, liposomes, niosomes, nanostructured lipid carrier, are being developed to enhance drug delivery to the brain. SLNs are particularly promising. These sub-micron colloidal carriers, composed of lipids dispersed in water, offer higher entrapment efficiency compared to niosomes and liposomes. By utilizing these modern drug delivery approaches, researchers aim to improve the efficacy of depression therapy by ensuring that a significant fraction of the delivered drug reaches its target by crossing the BBB.

KEYWORDS
Depression, Anti-Depressants, Blood Brain Barrier (BBB), Solid Lipid Nanoparticles (SLN), Intranasal Route

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Shreya Jadyal , Pallavi M. Chaudhari , "Solid Lipid Nanoparticles: A Promising Approach for Depression," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 693 - 701, 2025. DOI: 10.13189/app.2025.130419.

(b). APA Format:
Shreya Jadyal , Pallavi M. Chaudhari (2025). Solid Lipid Nanoparticles: A Promising Approach for Depression. Advances in Pharmacology and Pharmacy, 13(4), 693 - 701. DOI: 10.13189/app.2025.130419.