Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 713 - 720
DOI: 10.13189/app.2025.130421
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Formulation and Evaluation of Nasal In-situ Gel for Enhanced Nasal Drug Delivery
Shilpaja Chella 1, Saravanakumar Kasimedu 2,*
1 Department of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), India
2 Department of Pharmaceutics, Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India
ABSTRACT
The creation of an in-situ nasal gel of Metoclopramide Hydrochloride represents a promising innovation in drug delivery technology, providing an effective and patient-friendly alternative to conventional oral formulations. The prolonged release and higher absorption attained by this formulation may result in better treatment outcomes for patients suffering from chemotherapy-induced nausea and migraines. All formulations were thoroughly tested for physicochemical parameters such as pH, viscosity, mucoadhesive strength and drug content to ensure they satisfied the requirements for nasal delivery. In-vitro dissolution studies were performed to examine the gel's drug release profile and the results revealed that the gel has sustained release characteristics, which are critical for sustaining therapeutic drug concentrations over time. Increasing the concentration of mucoadhesive polymers (Poloxamer 407 and Carbopol 934) enhanced viscosity and mucoadhesive strength, resulting in a more controlled release of Metoclopramide Hydrochloride from the formulation. Poloxamer 407, a mucoadhesive polymer, Carbopol 934, a sensitive to pH polymer and PEG 400, a permeation enhancer were all incorporated in the formulation. In-vitro dissolving studies were used to characterize the release profile of Metoclopramide Hydrochloride from nasal gel formulations. The results showed that increasing the concentration of the mucoadhesive and pH-sensitive polymers (Poloxamer 407 and Carbopol 934) resulted in an increase in gel viscosity and mucoadhesive strength. This increase in viscosity helped to produce a more robust gel network, slowing the drug's diffusion and resulting in a more regulated and prolonged release over time. The optimal formulation, with carefully balanced polymer concentrations, demonstrated effective sol-gel conversion, sustained drug release, and improved bioavailability.
KEYWORDS
Sustained Release, Mucoadhesive Strength, Nasal Mucosa, Permeation, Gelling Agent
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Shilpaja Chella , Saravanakumar Kasimedu , "Formulation and Evaluation of Nasal In-situ Gel for Enhanced Nasal Drug Delivery," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 713 - 720, 2025. DOI: 10.13189/app.2025.130421.
(b). APA Format:
Shilpaja Chella , Saravanakumar Kasimedu (2025). Formulation and Evaluation of Nasal In-situ Gel for Enhanced Nasal Drug Delivery. Advances in Pharmacology and Pharmacy, 13(4), 713 - 720. DOI: 10.13189/app.2025.130421.