Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 730 - 736
DOI: 10.13189/app.2025.130423
Reprint (PDF) (996Kb)
Preclinical Evaluation of Anti-Hemorrhoidal Activity of L-carnitine-L-tartrate (LCLT) in Rats
Avinash A. Gunjal *, Ashish V. Kulkarni , Devendra S. Shirode , Prasad K. Bairagi , Vasant Y. Chavan , Niraj S. Vyawahare
Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044, Maharashtra, India
ABSTRACT
Background and Objectives: L-carnitine (LC), a critical component in producing cellular energy and the catabolism of fatty acids across various species including mammals, plants, and specific bacteria, is recognized for its anti-inflammatory and antioxidant activities. The primary goal of this investigation was to examine the potential of L-carnitine-L-tartrate (LCLT) as a supplement in treating hemorrhoids by using the Jatropha oil-induced hemorrhoid model. Materials and Methods: LCLT was sourced from Sigma Aldrich, USA. Hemorrhoids were experimentally induced in the anorectal regions of rats by applying Jatropha oil. The rats were subsequently administered LCLT (300 mg/kg, p.o and 500 mg/kg, p.o) along with Pilex granules (400 mg/kg, p.o) as a reference treatment, for 10 days. On the final day of treatment, anti-hemorrhoidal efficacy was assessed by measuring body weight, severity score, rectoanal coefficient (RAC), and conducting histopathological analysis of anorectal tissue. Results: LCLT supplementation resulted in a significant increase in body weight, decreased severity scores, and reduced rectoanal coefficient. Histopathological analysis further revealed a substantial decrease in inflammatory responses. Conclusion: The findings suggest that LCLT, likely through the action of carnitine, exhibits significant anti-inflammatory and antioxidant effects, making it a promising supplementary treatment for hemorrhoids.
KEYWORDS
L-carnitine-L-tartrate, Jatropha Oil, Anti-Inflammatory, Antioxidant, Anti-Hemorrhoidal Activity
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Avinash A. Gunjal , Ashish V. Kulkarni , Devendra S. Shirode , Prasad K. Bairagi , Vasant Y. Chavan , Niraj S. Vyawahare , "Preclinical Evaluation of Anti-Hemorrhoidal Activity of L-carnitine-L-tartrate (LCLT) in Rats," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 730 - 736, 2025. DOI: 10.13189/app.2025.130423.
(b). APA Format:
Avinash A. Gunjal , Ashish V. Kulkarni , Devendra S. Shirode , Prasad K. Bairagi , Vasant Y. Chavan , Niraj S. Vyawahare (2025). Preclinical Evaluation of Anti-Hemorrhoidal Activity of L-carnitine-L-tartrate (LCLT) in Rats. Advances in Pharmacology and Pharmacy, 13(4), 730 - 736. DOI: 10.13189/app.2025.130423.