Journals Information
Advances in Pharmacology and Pharmacy Vol. 13(4), pp. 737 - 746
DOI: 10.13189/app.2025.130424
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Alleviation of Chemotherapeutic Agent Induced Immunosuppression by Terminalia bellirica and Adhatoda vasica Linn. in Experimental Animals
Yogesh B. Gajmal 1,*, Padma L. Ladda 2, Nilofar S. Naikwade 2, Salma Bagwan 2
1 Appasaheb Birnale College of Pharmacy, Sangli - 416416, Affiliated to Shivaji University, Kolhapur, Maharashtra, India
2 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli - 416416, Affiliated to Shivaji University, Kolhapur, Maharashtra, India
ABSTRACT
Chemotherapy-induced immunosuppression is a common side effect of chemotherapeutic agents like 5-Fluorouracil (5-FU), which can compromise the body's immune defense and increase susceptibility to infections. The present study aimed to evaluate the potential of Terminalia bellirica fruit extract (TBFE) and Adhatoda vasica Linn. leaf extract (AVLE) in alleviating the immunosuppressive effects induced by 5-FU in Wistar albino rats. Phytochemical screening of TBFE and AVLE revealed the presence of bioactive compounds, including flavonoids, proteins, amino acids, glycosides, alkaloids, phenolic compounds, and tannins, which are likely responsible for their immunomodulatory effects. To assess the immunostimulatory activity, various in-vivo and ex-vivo methods were employed, including delayed hypersensitivity reaction, carbon clearance test, neutrophil adhesion test, and T-cell population analysis. The results demonstrated that both TBFE and AVLE significantly (P藗0.05) ameliorated the 5-FU-induced immunosuppression. Treatment with the extracts enhanced paw edema following antigen challenge, increased neutrophil counts, phagocytic activity, total lymphocyte count, and rossette formation. These findings suggest that the ethanolic extracts of TBFE and AVLE have the potential to restore immune function in 5-FU-treated rats, highlighting their potential as natural immunostimulants in chemotherapy-associated immunosuppression. Although promising, further studies are needed to explore the molecular mechanisms underlying their effects and to establish optimal dosages for clinical applications. This study contributes to the growing body of research on plant-based immunomodulators, with implications for improving the quality of life in cancer patients undergoing chemotherapy.
KEYWORDS
Terminalia bellirica, Adhatoda vasica Linn., Immunosupression, 5-FU, Carbon Clearance, Neutrophil Adhesion, T-Cell Population
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Yogesh B. Gajmal , Padma L. Ladda , Nilofar S. Naikwade , Salma Bagwan , "Alleviation of Chemotherapeutic Agent Induced Immunosuppression by Terminalia bellirica and Adhatoda vasica Linn. in Experimental Animals," Advances in Pharmacology and Pharmacy, Vol. 13, No. 4, pp. 737 - 746, 2025. DOI: 10.13189/app.2025.130424.
(b). APA Format:
Yogesh B. Gajmal , Padma L. Ladda , Nilofar S. Naikwade , Salma Bagwan (2025). Alleviation of Chemotherapeutic Agent Induced Immunosuppression by Terminalia bellirica and Adhatoda vasica Linn. in Experimental Animals. Advances in Pharmacology and Pharmacy, 13(4), 737 - 746. DOI: 10.13189/app.2025.130424.