Journals Information
Universal Journal of Medical Science(CEASE PUBLICATION) Vol. 2(4), pp. 43 - 50
DOI: 10.13189/ujmsj.2014.020402
Reprint (PDF) (313Kb)
Relation of Vaspin and Visfatin Levels with the Presence and the Severity of Coronary Artery Disease
Sahar EM El-Deek 1, Mohamed Aboel-Kassem F Abdelmegid 2,*, Mona M Soliman 3, Amr A Youssef 2
1 Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Cardiovascular Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt
3 Internal Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt
ABSTRACT
Background: Adipo卢cytokines may play role in pathogenesis of atherosclerosis. The association of the novel adipocytokines, vaspin and visfatin, with atherosclerosis coronary artery disease (CAD) is still obscure. Objectives: To investigate the relationship of vaspin and visfatin adipocytokines with the existence as well as the severity of CAD. Patients and Methods: A total of 87 patients who underwent coronary angiography due to symptoms of stable angina were enrolled in the study. They were divided into two groups; CAD group who have at least single vessel disease and normal group who have normal coronary arteries. The severity of CAD was assessed using coronary angiography by estimation the number of vessels affected and Gensini score. Results: Serum levels of vaspin were significantly lower and inversely, serum levels of visfatin were significantly higher in CAD group than normal (1.51 卤 0.99 渭g/L versus 4.54 卤 0.69 渭g/L for the former and 22.86 卤 4.68 渭g/L versus 13.43 卤 1.1 渭g/L for the later; p<0.0001 for each). Decreased vaspin and increased visfatin levels were correlated with CAD severity (p<0.0001 for each). There was a negative correlation between vaspin and the Gensini score and positive correlation between visfatin and Gensini score (r= -0.727, p<0.00001 and r= 0.798, p< 0.00001, respectively). Conclusion: Patients with CAD showed reduced vaspin and increased visfatin serum levels. Moreover, low vaspin and high visfatin levels were significantly correlated with CAD severity suggesting a link between atherosclerosis and adiposity.
KEYWORDS
Vaspin, Visfatin, Coronary Artery Disease
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sahar EM El-Deek , Mohamed Aboel-Kassem F Abdelmegid , Mona M Soliman , Amr A Youssef , "Relation of Vaspin and Visfatin Levels with the Presence and the Severity of Coronary Artery Disease," Universal Journal of Medical Science(CEASE PUBLICATION), Vol. 2, No. 4, pp. 43 - 50, 2014. DOI: 10.13189/ujmsj.2014.020402.
(b). APA Format:
Sahar EM El-Deek , Mohamed Aboel-Kassem F Abdelmegid , Mona M Soliman , Amr A Youssef (2014). Relation of Vaspin and Visfatin Levels with the Presence and the Severity of Coronary Artery Disease. Universal Journal of Medical Science(CEASE PUBLICATION), 2(4), 43 - 50. DOI: 10.13189/ujmsj.2014.020402.