Journals Information
Bioengineering and Bioscience(CEASE PUBLICATION) Vol. 3(3), pp. 29 - 38
DOI: 10.13189/bb.2015.030301
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Cross-species Comparison of CpG Density in the Promoter Regions of Protein Kinase Oncogenes
Gabriel G. Pioth 1, Kong-Nan Zhao 2, Guang B. Liu 1,*
1 School of Health and Wellbeing, Faculty of Health, Engineering and Sciences, University of Southern Queensland, Australia
2 Centre for Kidney Disease Research鈥擵enomics Research, The University of Queensland School of Medicine, Translational Research Institute, Australia
ABSTRACT
In this report, we investigated CpG density occurred in promoter regions (PRs) and downstream flanking regions (DFR) of 61 human protein kinase oncogenes (PKOs), together with other three species: chimpanzee, mouse and horse. The quantified numbers of CpGs in the PRs of human PKOs were much higher than those of chimpanzee, mouse and horse, suggesting that the CpG density changes among the four species are associated with species evolution. Human PKOs with relatively high number of CpGs in the PRs showed stronger gene expression than the mouse PKOs in tumour tissues, but not in normal tissues. Furthermore, human PKOs with extremely high density of CpGs in the PRs exhibited much lower expression in tumour tissues than in normal tissues. Our data initially suggest that the occurrence and density of CpGs in the PRs of PKOs play an important role in regulating gene expression associated with the tumorigenesis. Thus, further improvement of our understanding of the density and spatial arrangement of CpGs in the PRs of PKOs and other oncogenes involved in tumorigenesis is very important for providing preventive and therapeutic strategies for human cancer.
KEYWORDS
CpG Island, Protein Kinase Oncogene, Oncogenesis, Promoter Region, Transcription Start Sites
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Gabriel G. Pioth , Kong-Nan Zhao , Guang B. Liu , "Cross-species Comparison of CpG Density in the Promoter Regions of Protein Kinase Oncogenes," Bioengineering and Bioscience(CEASE PUBLICATION), Vol. 3, No. 3, pp. 29 - 38, 2015. DOI: 10.13189/bb.2015.030301.
(b). APA Format:
Gabriel G. Pioth , Kong-Nan Zhao , Guang B. Liu (2015). Cross-species Comparison of CpG Density in the Promoter Regions of Protein Kinase Oncogenes. Bioengineering and Bioscience(CEASE PUBLICATION), 3(3), 29 - 38. DOI: 10.13189/bb.2015.030301.