Journals Information
Advances in Diabetes and Metabolism(CEASE PUBLICATION) Vol. 3(3), pp. 17 - 25
DOI: 10.13189/adm.2015.030301
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Yacon (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Improved Erythrocyte Resistance to Oxidative Stress in Streptozotocin-induced Diabetic Rats
Mariia Khokhla 1,*, Olexandra Horbulinska 1, Halina Hachkova 1, Lidiya Mishchenko 2, Olexandr Shulga 3, Rosa Vildanova 3, Natalia Sybirna 1
1 Department of Biochemistry, Faculty of Biology, Ivan Franko National University of Lviv, Ukraine
2 Department of Virology, Institute of Biology, Taras Shevchenko National University of Kyiv, Ukraine
3 Department of Physical Chemistry of Combustible Minerals, L.M. Lytvynenko Institute of Physico-organic Chemistry and Coal Chemistry NAS of Ukraine, Ukraine
ABSTRACT
Yacon demonstrating prominent hypoglycemic action and having high content of biologically active compounds, is recognized for their ability to capture free radicals. This study is aimed to evaluate the influence of yacon leaves and root tubers water extracts and aqueous suspension of root tubers powder on rats' erythrocyte antioxidant defense system under the experimental diabetes mellitus type 1. Healthy animals and animals with diabetes mellitus were treated with water extracts of yacon leaves and root tubers at dose 70 or 500 mg / kg /day and with aqueous suspension of root tubers powder at dose 500 mg / kg /day or the same suspension which was stabilized by biocomplex PS. Thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activity in erythrocytes lysates were measured. Water extracts of yacon leaves and root tubers and aqueous suspension of root tubers powder possess significant antioxidant effect, which was indicated by the decrease of TBARS and PCC and increase in SOD, CAT and GPx activity. Root tubers of yacon water extract at a dose of 500 mg/kg/day and aqueous suspension of root tubers powder stabilized by biocomplex PS possess he most pronounced antioxidant effect.
KEYWORDS
Yacon, Erythrocyte, Antioxidant State, Diabetes
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Mariia Khokhla , Olexandra Horbulinska , Halina Hachkova , Lidiya Mishchenko , Olexandr Shulga , Rosa Vildanova , Natalia Sybirna , "Yacon (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Improved Erythrocyte Resistance to Oxidative Stress in Streptozotocin-induced Diabetic Rats," Advances in Diabetes and Metabolism(CEASE PUBLICATION), Vol. 3, No. 3, pp. 17 - 25, 2015. DOI: 10.13189/adm.2015.030301.
(b). APA Format:
Mariia Khokhla , Olexandra Horbulinska , Halina Hachkova , Lidiya Mishchenko , Olexandr Shulga , Rosa Vildanova , Natalia Sybirna (2015). Yacon (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Improved Erythrocyte Resistance to Oxidative Stress in Streptozotocin-induced Diabetic Rats. Advances in Diabetes and Metabolism(CEASE PUBLICATION), 3(3), 17 - 25. DOI: 10.13189/adm.2015.030301.