Journals Information
Advances in Pharmacology and Pharmacy Vol. 4(1), pp. 1 - 7
DOI: 10.13189/app.2016.040101
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Toxicological Impact of Co-treatment with Rifampicin and Tenofovir on the Renal Function of Male Albino Rats
Adikwu Elias 1,*, Igbans Rejoice Obele 2, Brambaifa Nelson 1
1 Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Rivers State, Nigeria
2 Department of Community Health Sciences, College of Health Technology, Otuogidi, Bayelsa State, Nigeria
ABSTRACT
This experimental study comparatively evaluated the toxicological effects of treatment with tenofovir, rifampicin and tenofovir- rifampicin (TDF-RIF) combination on kidney function and histology of male albino rats. Male albino rats used in this study were divided into five (5) groups A-E of sixteen (16) animals each. Animals in group A, (placebo control) were treated orally with normal saline, group B (solvent control) were treated orally with 0.1% ethanol while groups C-E were treated orally with 80 mg/kg of RIF, 32 mg/kg of TDF and a combination of TDF- RIF for 2-8 weeks respectively. Animals were sacrificed at the end of drug therapy, blood sample was collected, centrifuged and serum extracted for creatinine, urea and, uric acid evaluation. Kidney was harvested, weighed and examined for histopathological changes. Treatment with tenofovir-rifampicin combination had no significant (p<0.05) effect on absolute kidney weight when compared with treatment using individual doses of these drugs. Insignificant (p>0.05) time-dependent increases in serum creatinine, urea and uric acid levels were observed in animals treated with tenofovir-rifampicin combination when compared with treatment using individual doses of these drugs . Acute tubular necrosis, enlarged glomeruli and obliteration of the Bowman's capsule were observed in the kidneys of rats treated with tenofovir, rifampicin and a combination of tenofovir-rifampicin. This result shows that treatment with tenofovir-rifampicin combination in the management of human immunodeficiency virus /tuberculosis (HIV/TB) co-infection may not be associated with synergistic renal toxicity at the dose level used in this study.
KEYWORDS
Renal, Toxicity, Co-treatment, Tenofovir, Rifampicin, Rats
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Adikwu Elias , Igbans Rejoice Obele , Brambaifa Nelson , "Toxicological Impact of Co-treatment with Rifampicin and Tenofovir on the Renal Function of Male Albino Rats," Advances in Pharmacology and Pharmacy, Vol. 4, No. 1, pp. 1 - 7, 2016. DOI: 10.13189/app.2016.040101.
(b). APA Format:
Adikwu Elias , Igbans Rejoice Obele , Brambaifa Nelson (2016). Toxicological Impact of Co-treatment with Rifampicin and Tenofovir on the Renal Function of Male Albino Rats. Advances in Pharmacology and Pharmacy, 4(1), 1 - 7. DOI: 10.13189/app.2016.040101.