Journals Information
Universal Journal of Microbiology Research(CEASE PUBLICATION) Vol. 4(2), pp. 39 - 44
DOI: 10.13189/ujmr.2016.040201
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Urethelial Dysplasia and Desquamation Associated with Urinary Tract Infection: A Case-controlled Study
Jude Ogechukwu Okoye 1,*, Beatrice Omowumi Joel 2, Kenneth Onyenze 3
1 Histopathology Unit, Medical Laboratory Science Department, School of Public and Allied Health, Babcock University, Nigeria
2 Medical Laboratory Science Department, Faculty of Health Sciences, Madonna University, Elele Campus, Nigeria
3 Medical Microbiology Unit, Medical Laboratory Services, Madonna University Teaching Hospital, Nigeria
ABSTRACT
This study explored use of urine cytology as an early first-line approach in the laboratory diagnosis of dysplasia associated with urinary tract infection. Fifty (50) patients attending the obstetrics and gynaecology clinic at Madonna University Teaching Hospital and 50 apparently healthy subjects were recruited for the study. Urine samples were cultured and analyzed using the dipstick and Giemsa methods. The result of this study revealed significant higher number of nitrite positive samples, bacteria and pus cells when female test subjects were compared with apparently healthy female subjects (p<0.05). The frequency of Staphylococcus aureus, Escherichia coli, Streptococcus faecalis and C. albicans identified is 50.6, 27.3, 10.4 and 9.1 %, respectively while other isolated Coliforms amounted to 2.6%. Microscopy revealed marked cytolyses, desquamation and abnormal nuclear/cytoplasmic ratio. S. aureus and E. coli induced higher exfoliation and morphological change (72.7%) compared to other isolates. In conclusion, this study suggests that chronic bacterial infection could lead to accelerated desquamation of cells and urothelial carcinoma. More so, it revealed that females are at a higher risk of developing epithelial neoplasia following UTI when compared to the males. Thus, urine smears could be used as first line approach in the early diagnosis of urothelial malignancy.
KEYWORDS
Staphylococcus Aureus, Escherichia Coli, Desquamation, Urothelium, Dysplasia
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Jude Ogechukwu Okoye , Beatrice Omowumi Joel , Kenneth Onyenze , "Urethelial Dysplasia and Desquamation Associated with Urinary Tract Infection: A Case-controlled Study," Universal Journal of Microbiology Research(CEASE PUBLICATION), Vol. 4, No. 2, pp. 39 - 44, 2016. DOI: 10.13189/ujmr.2016.040201.
(b). APA Format:
Jude Ogechukwu Okoye , Beatrice Omowumi Joel , Kenneth Onyenze (2016). Urethelial Dysplasia and Desquamation Associated with Urinary Tract Infection: A Case-controlled Study. Universal Journal of Microbiology Research(CEASE PUBLICATION), 4(2), 39 - 44. DOI: 10.13189/ujmr.2016.040201.