Journals Information
Advances in Pharmacology and Pharmacy Vol. 1(2), pp. 68 - 73
DOI: 10.13189/app.2013.010204
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Evaluation of Efficacy and Safety of Premixed Parenteral Nutrition versus Customized Parenteral Nutrition in a Large Teaching Hospital
Teresa Pounds1, Annesha Lovett2,*, Susiana Eng2, Khalid Iqbal3, Israel Orija4, Jessica Chmielewski5
1 BCNSP Atlanta Medical Center, Department of Pharmacy 303 Parkway Drive Northeast, Atlanta, GA 30312
2 Mercer University, College of Pharmacy & Health Sciences, 3001 Mercer University Drive, Atlanta, GA 30341-4155
3 Atlanta South Nephrology, 1275 Cleveland Avenue, East Point, GA 30344
4 Atlanta Medical Center, Department of Endocrinology, 303 Parkway Drive Northeast, Atlanta, GA 30312
5 Cartersville Medical Center ,Department of Pharmacy ,960 Joe Frank Harris Pkwy SE , Cartersville, GA 30120
ABSTRACT
In the last two decades, there has been a significant degree of controversy surrounding the use of standardized parenteral solutions. Opponents of standardized parenteral nutrition claim that individualized parenteral nutrition is necessary because the critically ill patient requires daily manipulation of macro- and micro-nutrients secondary to stress associated with complex ailments. The purpose of this study was to determine if premixed parenteral nutrition solutions were equally safe and efficacious, while being less costly, in managing parenteral nutrition of patients at a large metropolitan teaching hospital, as compared to customized parenteral nutrition solutions. This was a randomized controlled trial with no placebo involving 100 patients requiring central parenteral nutrition. Consenting patients received either customized parenteral nutrition or premixed double chamber parenteral nutrition containing protein, carbohydrates and electrolytes. Vitamins and trace elements were added as needed. Each subject enrolled in the study was followed until the parenteral nutrition was either discontinued, the patient was transferred from the facility, or the patient expired during the study. Premixed and customized parenteral nutrition solutions were shown to be equally efficacious in patients as their blood glucose, fluid status, nutritional markers, serum electrolytes, phosphate, and magnesium values were within normal limits (p<.05). Premixed parenteral nutrition is associated with significantly better safety as compared to customized parenteral nutrition [11]. Furthermore, the cost difference was $41,934 when comparing the premixed formulation to the customized solution. In this study, premixed parenteral nutrition solutions were equally safe, effective, and less costly than customized parenteral nutrition formulas. Patients receiving premixed parenteral nutrition experienced less adverse drug reactions and metabolic abnormalities than patients receiving customized parenteral nutrition.
KEYWORDS
Parenteral Formulas/Compounding, Nutrition, Parenteral Nutrition
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Teresa Pounds , Annesha Lovett , Susiana Eng , Khalid Iqbal , Israel Orija , Jessica Chmielewski , "Evaluation of Efficacy and Safety of Premixed Parenteral Nutrition versus Customized Parenteral Nutrition in a Large Teaching Hospital," Advances in Pharmacology and Pharmacy, Vol. 1, No. 2, pp. 68 - 73, 2013. DOI: 10.13189/app.2013.010204.
(b). APA Format:
Teresa Pounds , Annesha Lovett , Susiana Eng , Khalid Iqbal , Israel Orija , Jessica Chmielewski (2013). Evaluation of Efficacy and Safety of Premixed Parenteral Nutrition versus Customized Parenteral Nutrition in a Large Teaching Hospital. Advances in Pharmacology and Pharmacy, 1(2), 68 - 73. DOI: 10.13189/app.2013.010204.