Journals Information
Advances in Pharmacology and Pharmacy Vol. 1(2), pp. 95 - 101
DOI: 10.13189/app.2013.010208
Reprint (PDF) (726Kb)
Microwave Induced Solid Dispersion as a Novel Technique for Enhancing Dissolution Rate of Repaglinide
Laxmikant Zawar1,*, Sanjay Bari2
1 Department of Pharmaceutics and Quality Assurance, R C Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur 425405, India
2 Principal, H R Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur 425405, India
ABSTRACT
The aim of the present study was to enhance the solubility, dissolution rate and thus antihyperglycemic activity of a poorly soluble, BCS class II drug repaglinide, using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. Solid dispersions were prepared by kneading, solvent evaporation, conventional fusion method and microwave induced fusion methods. The dispersions were evaluated for various in vitro parameters such as solubility study, dissolution study, fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). Microwave induced solid dispersions exhibited significant improvement in solubility and dissolution rate compared to that of pure drug. Results of DSC, XRD and SEM study showed translation of crystalline form of RG to amorphous form. Thus, microwave technology offers a simple, efficient, solvent free promising alternative method to prepare solid dispersion of RG with significant enhancement of the in vitro dissolution rate.
KEYWORDS
Microwave, Repaglinide, Solubility, Dissolution Rate
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Laxmikant Zawar , Sanjay Bari , "Microwave Induced Solid Dispersion as a Novel Technique for Enhancing Dissolution Rate of Repaglinide," Advances in Pharmacology and Pharmacy, Vol. 1, No. 2, pp. 95 - 101, 2013. DOI: 10.13189/app.2013.010208.
(b). APA Format:
Laxmikant Zawar , Sanjay Bari (2013). Microwave Induced Solid Dispersion as a Novel Technique for Enhancing Dissolution Rate of Repaglinide. Advances in Pharmacology and Pharmacy, 1(2), 95 - 101. DOI: 10.13189/app.2013.010208.