Journals Information
International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION) Vol. 4(1), pp. 11 - 19
DOI: 10.13189/ijnbs.2016.040102
Reprint (PDF) (449Kb)
Low-dose L-methionine-associated Changes in Behavioural Indices in Young Rats
Adejoke Y. Onaolapo
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Nigeria
ABSTRACT
Objective: The study objectives were to investigate the effects of L-methionine (at low doses) on open-field novelty-induced behaviours, anxiety-related behaviours, working-memory and brain S-adenosyl-methionine (SAMe) levels in young rats. This was with a view to determine whether administration of low doses of L-methionine can significantly alter behavioural parameters, working-memory and brain SAMe levels, or not. Methodology: Wistar rats (40-45 g each) were given distilled water or L-methionine (5 and 10 mg/kg body weight) orally for 21 days. Behaviours were assessed after the first and last dose of L-methionine. Results: In the open field, significant increases in horizontal locomotion and rearing were seen after the first dose, while repeated administration led to their suppression. Suppression of grooming behaviour was observed at both times of assessment. Working-memory in the radial-arm maze was significantly reduced following repeated administration; while the elevated plus-maze test revealed anxiolytic responses following both acute and repeated administration. Patterns of changes in horizontal locomotion in the y-maze and radial-arm maze were similar to that of the open-field. There was no significant difference in brain levels of SAMe at end of study. Conclusion: The study demonstrated an association between low dose L-methionine administration and behavioural changes in young rats. It therefore brings to light, the behavioural changes that may occur due to addition of low doses of L-methionine to the diet.
KEYWORDS
Amino Acid, Brain, Behaviour, Memory, Spontaneous-behaviour, Anxiety
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Adejoke Y. Onaolapo , "Low-dose L-methionine-associated Changes in Behavioural Indices in Young Rats," International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION), Vol. 4, No. 1, pp. 11 - 19, 2016. DOI: 10.13189/ijnbs.2016.040102.
(b). APA Format:
Adejoke Y. Onaolapo (2016). Low-dose L-methionine-associated Changes in Behavioural Indices in Young Rats. International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION), 4(1), 11 - 19. DOI: 10.13189/ijnbs.2016.040102.