Journals Information
International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION) Vol. 4(2), pp. 21 - 31
DOI: 10.13189/ijnbs.2016.040201
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Zinc Tempers Haloperidol-induced Behavioural Changes in Healthy Mice
Onaolapo OJ 1, Ayanwale T 2, Agoi O 2, Adetimehin C 2, Onaolapo AY. 2,*
1 Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Nigeria
2 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Nigeria
ABSTRACT
Objective: Behavioural changes secondary to haloperidol/zinc administration were studied, with a view to understanding the patterns of behavioural responses that may be exhibited after such treatment in healthy mice. Methodology: 6 month old Swiss mice (24-30 g each, n=12), were given vehicle (distilled water), haloperidol (2 mg/kg), zinc (as Zinc gluconate, 2.5 and 5 mg/kg) or haloperidol/zinc combination, orally for 21 days. Behaviours were assessed after the first and last dose of haloperidol/zinc. Results: Zinc administration led to a significant reduction of haloperidol-induced suppression of horizontal locomotion, rearing and grooming behaviours. Zn also prevented the deterioration in Y-maze and radial-arm maze working-memory that was associated with repeated haloperidol administration. Finally, an enhanced anxiolytic effect was seen with co-administration of haloperidol with the lower dose of zinc. Conclusion: Co-administration of haloperidol with zinc can reduce some unwanted effects that are known to be associated with haloperidol therapy; hence zinc may be a beneficial adjunct to haloperidol administration.
KEYWORDS
Antipsychotic, Neurobehaviour, Supplement, Trace Element, Memory, Novelty-induced Behaviour, Anxiety
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Onaolapo OJ , Ayanwale T , Agoi O , Adetimehin C , Onaolapo AY. , "Zinc Tempers Haloperidol-induced Behavioural Changes in Healthy Mice," International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION), Vol. 4, No. 2, pp. 21 - 31, 2016. DOI: 10.13189/ijnbs.2016.040201.
(b). APA Format:
Onaolapo OJ , Ayanwale T , Agoi O , Adetimehin C , Onaolapo AY. (2016). Zinc Tempers Haloperidol-induced Behavioural Changes in Healthy Mice. International Journal of Neuroscience and Behavioral Science(CEASE PUBLICATION), 4(2), 21 - 31. DOI: 10.13189/ijnbs.2016.040201.