Journals Information
Universal Journal of Clinical Medicine(CEASE PUBLICATION) Vol. 1(2), pp. 28 - 33
DOI: 10.13189/ujcm.2013.010203
Reprint (PDF) (370Kb)
The Usefulness of Cystatin C as a Marker for Chronic Kidney Disease
Zati Iwani AK*, Ruziana Mona WZ, Nor Idayu R, Wan Nazaimoon WM
Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur
ABSTRACT
Background : Diagnostic marker to detect chronic kidney disease (CKD) at early stage is important as early intervention can slow the loss of kidney function. Plasma or serum Cystatin C (CysC) is said to be a superior marker for CKD compared to serum creatinine (SCr) to detect mild GFR reduction between 60 and 90 ml/min/1.73m2. Methods: We analysed blood and urine samples from 418 normal subjects and 37 Type 2 diabetes patients (T2DM) with CKD. Estimation of glomerular filtration rate (eGFR) was determined using CKD-EPI. We compared the level CysC by CKD staging. Then, the correlation CysC and eGFR were compared between the normal subjects and the T2DM patients.Results : Plasma CysC level increase with the progression of CKD and was significantly elevated in CKD stage 2. CysC levels were highly correlated with eGFR in the T2DM patients. Conclusion: These results indicated that CysC have the potential of detecting early CKD especially in those with high risk such as the T2DM patients and also hypertension.
KEYWORDS
Chronic Kidney Disease, Cystatin C, Estimated Glomerular Filtration Rate, Albumin-Creatinine Ratio, Diabetes, Hypertension
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Zati Iwani AK , Ruziana Mona WZ , Nor Idayu R , Wan Nazaimoon WM , "The Usefulness of Cystatin C as a Marker for Chronic Kidney Disease," Universal Journal of Clinical Medicine(CEASE PUBLICATION), Vol. 1, No. 2, pp. 28 - 33, 2013. DOI: 10.13189/ujcm.2013.010203.
(b). APA Format:
Zati Iwani AK , Ruziana Mona WZ , Nor Idayu R , Wan Nazaimoon WM (2013). The Usefulness of Cystatin C as a Marker for Chronic Kidney Disease. Universal Journal of Clinical Medicine(CEASE PUBLICATION), 1(2), 28 - 33. DOI: 10.13189/ujcm.2013.010203.