Journals Information
Advances in Pharmacology and Pharmacy Vol. 5(1), pp. 1 - 11
DOI: 10.13189/app.2017.050101
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Subchronic Amitriptyline Influences Open-field Behaviours and Spontaneous Working-memory in Healthy Mice
Onaolapo Olakunle James 1, Olabintan Olusegun Oyewole 1, Onaolapo Adejoke Yetunde 2,*
1 Department of Pharmacology, Ladoke Akintola University of Technology, Nigeria
2 Department of Anatomy, Ladoke Akintola University of Technology, Nigeria
ABSTRACT
Objective: We assessed the effects of amitriptyline on open-field locomotion, stereotypic behaviours and spatial working-memory in healthy mice. Method: Five groups of mice were administered vehicle (distilled water), scopolamine (2 mg/kg), or one of three doses of amitriptyline (5, 10 and 15 mg/kg) for 21 days. Behaviours were assessed after the first and final dose of treatment. Result: Administration of the first dose of amitriptyline was associated with enhanced open-field horizontal locomotion, rearing and grooming; with repeated administration, there was suppression of horizontal locomotion and rearing. A dose-related decrease in Y-maze and radial-arm maze spatial working-memory was also observed after repeated administration. Compared to scopolamine, amitriptyline was associated with a significant reduction in open-field behaviours, but a significantly-higher spatial working-memory score. Conclusion: Repeated administration of amitriptyline in healthy mice was associated with suppression of locomotion and grooming; working-memory deficits were also observed. However, working-memory task performance is significantly better than the scopolamine group.
KEYWORDS
Amitriptyline, Antidepressant, Amnesia, Novelty-induced Behaviours, Working-memory, Scopolamine
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Onaolapo Olakunle James , Olabintan Olusegun Oyewole , Onaolapo Adejoke Yetunde , "Subchronic Amitriptyline Influences Open-field Behaviours and Spontaneous Working-memory in Healthy Mice," Advances in Pharmacology and Pharmacy, Vol. 5, No. 1, pp. 1 - 11, 2017. DOI: 10.13189/app.2017.050101.
(b). APA Format:
Onaolapo Olakunle James , Olabintan Olusegun Oyewole , Onaolapo Adejoke Yetunde (2017). Subchronic Amitriptyline Influences Open-field Behaviours and Spontaneous Working-memory in Healthy Mice. Advances in Pharmacology and Pharmacy, 5(1), 1 - 11. DOI: 10.13189/app.2017.050101.