Journals Information
Advances in Pharmacology and Pharmacy Vol. 5(2), pp. 25 - 30
DOI: 10.13189/app.2017.050202
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Evaluation of the Anticonvulsant Activity of the Hydroethanolic Extract of Crinum scillifolium Bulbs (Amaryllidaceae) in Experimental Animals
Koua Kadio Brou Donald 1,*, Kouakou Sylvain Landry 2, Yapo Adou Francis 1, Yapi Houphouet Felix 1, N'tamon Amon Diane Marina 3, Miezan Bile Aka Patrice 1, Kouakou Gis猫le Siransy 2
1 Laboratory of Biochemical Pharmacodynamics, Unit茅 de Formation et de Recherche (UFR) Biosciences, Felix Houphouet Boigny University, C么te d'Ivoire
2 Department of Pharmacology, Clinical and Therapeutical Pharmacy, Unit茅 de Formation et de Recherche (UFR) Pharmaceutical and Biologic Sciences, Felix Houphouet Boigny University, C么te d'Ivoire
3 Laboratory of Organic Chemistry and Natural Substances, Unit茅 de Formation et de Recherche (UFR) Sciences of Structures of Matter and Technology, Felix Houphouet Boigny University, C么te d'Ivoire
ABSTRACT
Crinum species is frequently used for the treatment of nervous disorders such as epilepsy. This study aimed to investigate the anticonvulsant activity of the hydroethanolic extract of the Crinum scillifolium bulbs in chemoconvulsant-induced seizures in mice. The anticonvulsant activity of the extract (25, 50, 100, 200 and 400mg/kg), was investigated in isoniazid (INH)-induced seizures in mice. The hydroethanolic extract protected mice from INH-induced seizures in a dose-dependent manner. 100% of protection was observed when the animals were treated with 200 and 400mg/kg of hydroethanolic extract of Crinum scillifolium. At Dose of 50 and 100mg/kg 83% protection was observed; the onset of convulsion significant was delayed, and no mortality was found of the mice against isoniazid-induced convulsion. Mice pretreated with hydroethanolic extract at the dose of 25mg/kg reduced mortality to 27% and significant delayed the onset of death (p<0.01). In conclusion, Crinum scillifolium was revealed possessing anticonvulsant effects in mice, via the GABAergic neurotransmission.
KEYWORDS
Epilepsy, Anticonvulsant, Crinum scillifolium, Isoniazid, Mice
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Koua Kadio Brou Donald , Kouakou Sylvain Landry , Yapo Adou Francis , Yapi Houphouet Felix , N'tamon Amon Diane Marina , Miezan Bile Aka Patrice , Kouakou Gis猫le Siransy , "Evaluation of the Anticonvulsant Activity of the Hydroethanolic Extract of Crinum scillifolium Bulbs (Amaryllidaceae) in Experimental Animals," Advances in Pharmacology and Pharmacy, Vol. 5, No. 2, pp. 25 - 30, 2017. DOI: 10.13189/app.2017.050202.
(b). APA Format:
Koua Kadio Brou Donald , Kouakou Sylvain Landry , Yapo Adou Francis , Yapi Houphouet Felix , N'tamon Amon Diane Marina , Miezan Bile Aka Patrice , Kouakou Gis猫le Siransy (2017). Evaluation of the Anticonvulsant Activity of the Hydroethanolic Extract of Crinum scillifolium Bulbs (Amaryllidaceae) in Experimental Animals. Advances in Pharmacology and Pharmacy, 5(2), 25 - 30. DOI: 10.13189/app.2017.050202.