Journals Information
Advances in Pharmacology and Pharmacy Vol. 6(2), pp. 43 - 49
DOI: 10.13189/app.2018.060202
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Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients
Jubran K. Hassan 1,*, Adheed Khalid Sharrad 1, Falah Hassan Sheri 2
1 Department of Clinical Pharmacy, College of Pharmacy, University of Basra, Iraq
2 Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basra, Iraq
ABSTRACT
Background: Diabetes associated with multiple metabolic problems in the body, including bone mineralization remodeling, osteoporosis and increase risk of fracture. Quercetin is natural flavonoids and according to animal studies; it has potent antioxidant, antidiabetic and protective effect against bone loss due to various causes. Objectives: explore effect of quercetin as nutritional supplement administrated orally on some bone mineralization bio-markers such as calcium, vitamin D and osteocalcin in Iraqi diabetic patients. Methods: interventional double-blind placebo randomized controlled study in which 40 patients with type 2 diabetes mellitus (age range 40-45) assigned randomly (using simple randomization) in either control (n=20) or study (n=20) group. Study group received Quercetin oral supplement as 500mg capsule once daily for three months. Venous blood was used for measuring Serum calcium, 25(OH) vitamin D and osteocalcin at base line and after 3 months. Results: After 3 months treatment with Quercetin; levels of Osteocalcin (28.1卤7.6), serum calcium (9.2卤1.8) and 25(OH) vitamin D (26.6卤8.7) were significantly (p<0.05) higher than pretreatment values of osteocalcin (24.0卤8.6); serum calcium (7.0卤2.2) and 25(OH) vitamin D (20.6卤7.7) and control values of serum calcium (6.8卤2.0) and 25(OH) vitamin D (20.8卤7.4), but not Osteocalcin (25.2卤9.0). There was also significant correlation between use of quercetin; elevation of serum calcium and osteocalcin (r= 0.454; p= 0.032), indicating modulation in bone mineralization. Conclusions: Quercetin's use in diabetic patients may elevate Serum level of Calcium; 25(OH) vitamin D and may modulate bone mineralization represented by elevation of osteocalcin.
KEYWORDS
Quercetin, Osteocalcin, Diabetes, 25(OH) Vitamin D, Calcium
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Jubran K. Hassan , Adheed Khalid Sharrad , Falah Hassan Sheri , "Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients," Advances in Pharmacology and Pharmacy, Vol. 6, No. 2, pp. 43 - 49, 2018. DOI: 10.13189/app.2018.060202.
(b). APA Format:
Jubran K. Hassan , Adheed Khalid Sharrad , Falah Hassan Sheri (2018). Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients. Advances in Pharmacology and Pharmacy, 6(2), 43 - 49. DOI: 10.13189/app.2018.060202.