Journals Information
Universal Journal of Clinical Medicine(CEASE PUBLICATION) Vol. 6(1), pp. 1 - 9
DOI: 10.13189/ujcm.2018.060101
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Investigation of the Relationship between Breast Cancers ‎and HPVs
Mervat Saeed 1,*, Yasemin Zer ‎ 1, Zehra Bozdağ 2
1 Department of Medical Microbiology, Institute of Medical Sciences, University of Gaziantep, Turkey
2 Department of Pathology, Gaziantep University ‎Hospital, Turkey
ABSTRACT
High-risk human papillomaviruses (HR-HPVs) ‎have been implicated in ‎the aetiology of a variety of human ‎cancers, including cervical, colorectal, and head and ‎neck ‎‎(HN); also, (HPVs) may be important risk factors for breast ‎carcinogenesis and ‎metastasis. Previous studies that ‎evaluated the prevalence of HPVs in breast cancer ‎have ‎generated considerable controversy. Based on this ‎hypothesis, we aimed to investigate ‎the prevalence of HPV ‎infection in invasive breast cancer tissues. ‎Our study included 80 paraffin ‎blocks taken from breast ‎cancerous tissue specimens of ‎Turkish female patients and 13 controls (cervical ‎cancerous ‎tissue specimens) in Research and Practice Hospital- ‎Sahinbey -Gaziantep ‎University, using PCR (HPV Genotypes ‎‎14 Real-TM Quant / Italy) to detect the HR-‎HPV DNA. ‎In our results: HR-HPV DNA was evidenced in (10%) of the breast ‎cancer and in (92.3%) of ‎the controls (p < 0.05). HPV (45-56-68) were the most prevalent genotypes in ‎breast ‎cancer cases. Also HPV co-infection was high (75%) in ‎positive breast cancerous ‎samples.‎ Our data propose Human papilloma viruses ‎may play a role as a possible ‎causal relationship, or ‎mediation or even as a cofactor in the development of some ‎types ‎of breast cancer, this still needs to be confirmed by prospective studies.
KEYWORDS
HR-HPV, Breast Cancer, Multiple Real Time ‎PCR
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Mervat Saeed , Yasemin Zer ‎ , Zehra Bozdağ , "Investigation of the Relationship between Breast Cancers ‎and HPVs," Universal Journal of Clinical Medicine(CEASE PUBLICATION), Vol. 6, No. 1, pp. 1 - 9, 2018. DOI: 10.13189/ujcm.2018.060101.
(b). APA Format:
Mervat Saeed , Yasemin Zer ‎ , Zehra Bozdağ (2018). Investigation of the Relationship between Breast Cancers ‎and HPVs. Universal Journal of Clinical Medicine(CEASE PUBLICATION), 6(1), 1 - 9. DOI: 10.13189/ujcm.2018.060101.