Journals Information
Advances in Diabetes and Metabolism(CEASE PUBLICATION) Vol. 6(2), pp. 16 - 23
DOI: 10.13189/adm.2018.060202
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Age of Appearance of Diabetes Autoantibodies in Type 1a Diabetics and Their Siblings in C么te D'ivoire
Tr茅bissou A茂ss茅 Florence Judith 1,2,*, Sanogo Mamadou 3, Sibailly Pascal 4, Ankotch茅 Amos 4, Lokrou Adrian 3, Hatem Masmoudi 5, Yapo Adou Francis 1, Djaman Allico Joseph 1,6
1 Laboratory of Biochemistry-Pharmacodynamics, Faculty of Biosciences, Felix Houphou毛t Boigny University, Cote d'Ivoire
2 National Institute of Public Health, Abidjan, C么te d'Ivoire
3 Diabetology and Endocrinology Department, University Hospital Center (U.H.C) of Yopougon, C么te d'Ivoire
4 Diabetes Clinic, University Hospital Center (U.H.C) of Treichville, C么te d'Ivoire
5 Laboratory of Immunology, Hospital Habib Bourguiba of Sfax, Tunisia
6 Department of Medical Biochemistry and Fundamental, Pasteur Institute of C么te d'Ivoire, C么te d'Ivoire
ABSTRACT
Diabetes autoantibodies, which are important markers of classification and prevention of type 1 diabetes, are absent in the diabetes care in C么te d'Ivoire. The study aim was to determine the age at which these autoantibodies were at their highest levels in type 1A diabetic patients (T1D) and their siblings in C么te d鈥橧voire. The study population is composed of 28 T1D patients and 59 siblings, aged from 5 to 21 years. T1D were followed up in the U.H.C Endocrinology departments of Yopougon and Treichville, in the District of Abidjan. Anti-GAD and anti-IA2 autoantibodies were researched by ELISA and anti-ICA autoantibodies by indirect immunofluorescence on monkey pancreas. The peaks of anti-GAD and anti-IA2 autoantibodies were observed respectively at 9 years old (604.30卤521.70 IU/ml) and 10 years old (125.10卤90.10 IU/ml) in T1D. In siblings, the peaks of anti-GAD and anti-IA2 autoantibodies were observed respectively at 13 years old (137 IU/ml) and 10 years old (53卤40 IU/ml). The peak of diabetes autoantibodies in T1D and their siblings in C么te d'Ivoire is at a very young age noted. This could explain the high mortality rate among T1D youth in C么te d'Ivoire.
KEYWORDS
Diabetes Autoantibodies, Type 1A Diabetes, Age of Peak of Autoantibodies, C么te d'Ivoire
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Tr茅bissou A茂ss茅 Florence Judith , Sanogo Mamadou , Sibailly Pascal , Ankotch茅 Amos , Lokrou Adrian , Hatem Masmoudi , Yapo Adou Francis , Djaman Allico Joseph , "Age of Appearance of Diabetes Autoantibodies in Type 1a Diabetics and Their Siblings in C么te D'ivoire," Advances in Diabetes and Metabolism(CEASE PUBLICATION), Vol. 6, No. 2, pp. 16 - 23, 2018. DOI: 10.13189/adm.2018.060202.
(b). APA Format:
Tr茅bissou A茂ss茅 Florence Judith , Sanogo Mamadou , Sibailly Pascal , Ankotch茅 Amos , Lokrou Adrian , Hatem Masmoudi , Yapo Adou Francis , Djaman Allico Joseph (2018). Age of Appearance of Diabetes Autoantibodies in Type 1a Diabetics and Their Siblings in C么te D'ivoire. Advances in Diabetes and Metabolism(CEASE PUBLICATION), 6(2), 16 - 23. DOI: 10.13189/adm.2018.060202.