Journals Information
International Journal of Biochemistry and Biophysics(CEASE PUBLICATION) Vol. 6(4), pp. 77 - 82
DOI: 10.13189/ijbb.2018.060401
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Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats
Koua Kadio Brou Donald 1,*, Iri茅-N鈥檊uessan Amenan Genevi猫ve 2, Effo Kouakou Etienne 2, Kouakou Sylvain Landry 2, Ayoman Thierry Lenoir djadji 2, Tetchi Achille Fabrice 3, Yapi Houphou毛t Felix 1
1 Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphou毛t-Boigny University, C么te d'Ivoire
2 Department of Pharmacology, Clinical and Therapeutical Pharmacy UFR Pharmaceutical and Biologic Sciences, Felix Houphou毛t-Boigny University, C么te d'Ivoire
3 Laboratory of Food Biochemistry and Tropical Products Technology, University of Nangui Abrogoua, C么te d'Ivoire
ABSTRACT
Aim of study: Inflammation was associated with many diseases in humans. Crinum species have a considerable medicinal reputation as potent folkloric remedies. The main objective of the study was to evaluate the anti-inflammatory activity of aqueous and hydroethanolic extracts of Crinum scillifolium bulbs in in vivo models. Materials and methods: The anti-inflammatory effect of Crinum scillifolium extracts was also evaluated in carrageenan-induced paw edema models and C-reactive protein (CRP) levels was measured. Two doses 100 and 200 mg/kg body weight for each extract, were tested. The results obtained were compared with those of the standard drug (Diclofenac at 25 mg/kg body weight) and those of the control (normal saline). Results: The results showed a highly significant decrease in the edema size (p < 0.01) and significant decrease in CRP values (p < 0.01) compared to control group when the animals were treated with diclofenac at 25 mg/kg, and 200 mg/kg of aqueous and hydroethanolic extracts. Conclusion: The study suggests that the extracts possess enough potential to reduce inflammation on rat model and directs the importance of further research and development of novel anti-inflammatory agents.
KEYWORDS
Crinum scillifolium, Inflammation, CRP, Carrageenan
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Koua Kadio Brou Donald , Iri茅-N鈥檊uessan Amenan Genevi猫ve , Effo Kouakou Etienne , Kouakou Sylvain Landry , Ayoman Thierry Lenoir djadji , Tetchi Achille Fabrice , Yapi Houphou毛t Felix , "Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats," International Journal of Biochemistry and Biophysics(CEASE PUBLICATION), Vol. 6, No. 4, pp. 77 - 82, 2018. DOI: 10.13189/ijbb.2018.060401.
(b). APA Format:
Koua Kadio Brou Donald , Iri茅-N鈥檊uessan Amenan Genevi猫ve , Effo Kouakou Etienne , Kouakou Sylvain Landry , Ayoman Thierry Lenoir djadji , Tetchi Achille Fabrice , Yapi Houphou毛t Felix (2018). Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats. International Journal of Biochemistry and Biophysics(CEASE PUBLICATION), 6(4), 77 - 82. DOI: 10.13189/ijbb.2018.060401.