Journals Information
Advances in Pharmacology and Pharmacy Vol. 8(3), pp. 41 - 50
DOI: 10.13189/app.2020.080302
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Fruiting Body of Pleurotus Ostreatus Reduces Serum Glucose and Modifies Oxidative Stress in Type 2 Diabetic: Drosophila Melanogaster (Fruit-Fly)
Omale S. 1,*, Aguiyi JC. 1, Bukar BB. 2, Ede SO. 2, Amagon KI. 2, Amagon L. 2, Usman O. 2, Chinello V. 3, Oshibanjo DO. 4
1 Department of Pharmacology and Toxicology Faculty of Pharmaceutical Sciences/Africa Centre of Excellence in Phytomedicine Research and Development (ACEPRD), University of Jos, Nigeria
2 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria
3 Molecular Laboratory Africa Centre of Excellence in Phytomedicine Research and Development, University of Jos, Nigeria
4 Department of Animal Production, Faculty of Agriculture, University of Jos, Nigeria
ABSTRACT
Mushrooms, which possess medicinal properties, are also considered a good source of food and basic nutrients. Diabetic patients now use edible mushrooms as a source of low-calorie food. Mushrooms are used to treat and prevent diseases such as diabetes, obesity, heart disease, hyperacidity, cancer, hypertension and also act as immune modulators. In this study, the antidiabetic and antioxidant effects of the fruiting body of Pleurotus ostreatus (PO) in sucrose-induced type-2 diabetic Drosophila melanogaster was investigated. The fresh fruiting body of PO was obtained from the mushroom farm of the Africa Centre of Excellence in Phytomedicine Research and Development (ACEPRD) and dried with the aid of the ASPRE dryer. The aqueous extract of the dried powder was used for the anti-diabetic and survival assay. The fly homogenate was evaluated for circulating glucose, total thiol, acetylcholinesterase, catalase and glutathione-S-transferase. PO was observed to prolong D. melanogaster鈥檚 survival time as more flies (> 50%) survived on the extract compared to control (47%), after 28 days. There was a significant (P < 0.05) decrease in the circulating glucose of the treated flies compared with those that were untreated; while no statistical (P > 0.05) difference was observed between the metformin and PO treated groups. In the antioxidant study, an insignificant (P > 0.05) difference between the untreated and treated groups was observed. Catalase activity showed a significant (P < 0.05) difference between the diabetic untreated and PO treated groups. We conclude that the fruiting body of P. ostreatus possessed potent hypoglycemic activities in D. melanogaster induced type-2 diabetes, possibly linked to its antioxidant property.
KEYWORDS
Antioxidants, Drosophila melanogaster, Glucose, Homogenate, Hyperglycemia, Pleurotus ostreatus, Type-2 diabetes
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Omale S. , Aguiyi JC. , Bukar BB. , Ede SO. , Amagon KI. , Amagon L. , Usman O. , Chinello V. , Oshibanjo DO. , "Fruiting Body of Pleurotus Ostreatus Reduces Serum Glucose and Modifies Oxidative Stress in Type 2 Diabetic: Drosophila Melanogaster (Fruit-Fly)," Advances in Pharmacology and Pharmacy, Vol. 8, No. 3, pp. 41 - 50, 2020. DOI: 10.13189/app.2020.080302.
(b). APA Format:
Omale S. , Aguiyi JC. , Bukar BB. , Ede SO. , Amagon KI. , Amagon L. , Usman O. , Chinello V. , Oshibanjo DO. (2020). Fruiting Body of Pleurotus Ostreatus Reduces Serum Glucose and Modifies Oxidative Stress in Type 2 Diabetic: Drosophila Melanogaster (Fruit-Fly). Advances in Pharmacology and Pharmacy, 8(3), 41 - 50. DOI: 10.13189/app.2020.080302.