Journals Information
Universal Journal of Food and Nutrition Science(CEASE PUBLICATION) Vol. 1(1), pp. 1 - 3
DOI: 10.13189/ujfns.2013.010101
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Cytotoxic Activity of Ethanolic Extract of Myristica Fragrans (Houtt) Against Seven Human Cancer Cell Lines
Ekta Prakash, Dwijendra. K.Gupta*
Biochemistry Department, Allahabad University, Allahabad, India
ABSTRACT
The objective of the present study was to evaluate the in-vitro anti-cancer effects of ethanolic extract of seed of Myristica fragrans (Houtt) against seven human cancer cell lines ascribed to central nervous system, Colon cell (Colon502713,Colo205), Liver(Hep-2), Lung (A-549), Ovary OVCAR-5 and Prostrate (PC-5). The SRB assay was used to test cytotoxic activity for all the cell lines. The activity was evaluated at 100碌g/ml concentration of test material. OVCAR-5 (Ovary) cell line showed highest cytotoxic activity (97%) Growth inhibition of colon 502713 and PC-5 (Prostrate) cell lines was 86%. SF-295(CNS) and Colo205 showed 73% growth inhibition, while Hep-2 (Liver) showed 72%. A-549 (Lung) showed no significant activity (50%). Our results indicate that the plant has a promising anti-cancer activity. The ethanolic extract of plant showed highest anti-cancer activity against OVCAR-5. Further investigation for active compound present in Myristica fragrans is required for cancer management and for the development of new anti- cancer drugs.
KEYWORDS
Myristica Fragrans (Houtt), Ethanolic Extract, OVCAR-5
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Ekta Prakash , Dwijendra. K.Gupta , "Cytotoxic Activity of Ethanolic Extract of Myristica Fragrans (Houtt) Against Seven Human Cancer Cell Lines," Universal Journal of Food and Nutrition Science(CEASE PUBLICATION), Vol. 1, No. 1, pp. 1 - 3, 2013. DOI: 10.13189/ujfns.2013.010101.
(b). APA Format:
Ekta Prakash , Dwijendra. K.Gupta (2013). Cytotoxic Activity of Ethanolic Extract of Myristica Fragrans (Houtt) Against Seven Human Cancer Cell Lines. Universal Journal of Food and Nutrition Science(CEASE PUBLICATION), 1(1), 1 - 3. DOI: 10.13189/ujfns.2013.010101.